Comparison of Mefenamic Acid, and Tranexamic Acid in Treatment of Hypermenorrhea

Sekhavat, L and Zare Tarazjani, Fatemeh and Karimzadeh, M.A (2006) Comparison of Mefenamic Acid, and Tranexamic Acid in Treatment of Hypermenorrhea. The Iranian Journal of Obstetrics, Gynecology and Infertility, 9 (2). pp. 17-22.

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Introduction: Excessive menstrual bleeding is a common complaint and each year around 5 of 30-49 year old women have this problem. The aim of this study is to compare the efficacy and acceptability of mefenamic acid and tranexamic acid for treating menorrhea. Attempts have been made to choose a more effective with less complications to treat hyper menorrhea. Materials and Methods: This study is a control trial study and the setting is Shahid Sedugh University, department of obstetrics and gynecology ,Yazd in 2001-2005. 75 women with excessive uterine bleeding (hyper menorrhea) were under treatment for five days from day 1 of menses during three consecutive menstrual periods. 36 patients were randomized to take mefenamic acid 500 mg, Tid; and 39 patientsto take 500 mg tranexamic acid, Qid. Menstrual loss was measured in three control menstrual periods and three menstrual periods during treatment. Duration of bleeding patient's estimated blood loss, sanitary towel usage and unwanted events were also taken into consideration. Results: mefenamic acid reduced blood loss by 20 and tranexamic acid reduced blood loss by 50 (P=0.001). Duration of bleeding was not different in patients treated with mefenamic acid and tranexamic acid. Conclusions: Tranexamic acid given during menstruation is a safe and highly effective treatment for excessive bleeding. Patients with dysfunctional uterine bleeding should be offered medical treatment with tranexamic acid before a decision is made about surgery.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 28 Sep 2017 14:53
Last Modified: 28 Sep 2017 14:53

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