The protective effect of infliximab against carbon tetrachloride-induced acute lung injury

Kurt, Aysel and Tumkaya, Levent and Yuce, Suleyman and Turut, Hasan and Cumhur Cure, Medine and Sehitoglu, Ibrahim and Kalkan, Yildiray and Pusuroglu, Gokhan and Cure, Erkan (2016) The protective effect of infliximab against carbon tetrachloride-induced acute lung injury. Iranian Journal of Basic Medical Sciences, 19 (6). pp. 685-691.

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Abstract

Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods:Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4. Results:TNF-α, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group. Conclusion:Ib as a strong TNF-α blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 28 Sep 2017 15:28
Last Modified: 28 Sep 2017 15:28
URI: http://eprints.mums.ac.ir/id/eprint/6367

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