Evaluation of phytochemicals, antioxidant and burn wound healing activities of Cucurbita moschata Duchesne fruit peel

Bahramsoltani, Roodabeh and Farzaei, Mohammad Hosein and Abdolghaffari, Amir Hossein and Rahimi, Roja and Samadi, Nasrin and Heidari, Mohammad and Esfandyari, Mohammadamin and Baeeri, Maryam and Hassanzadeh, Gholamreza and Abdollahi, Mohammad and Soltani, Saba and Pourvaziri, Ali and Amin, Gholamreza (2017) Evaluation of phytochemicals, antioxidant and burn wound healing activities of Cucurbita moschata Duchesne fruit peel. Iranian Journal of Basic Medical Sciences, 20 (7). pp. 798-805.

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Abstract

Objective(s): Cucurbita moschata Duchesne (pumpkin) is a well-known plant with several pharmacological effects. The aim of the present study was to assess burn wound healing activity of C. moschata peel extract (CE). Also, standardized CE was assessed for antioxidant activity and antibacterial effects against major pathogens of burns. Materials and Methods: Healing properties of topical preparation of 10 and 20 concentrations of CE were assessed on second degree burn in rats during a 14-day period as well as histological studies, total antioxidant power, lipid peroxidation and total thiol content of skin tissue samples. Results: Radical scavenging IC50 and ferric-reducing antioxidant power value were 4.015±0.20 mg/ml and 142.63±2.65 mmol Fe2+/g, respectively. Total mucilage content was 13.8. The optimal results were obtained by 20 CE that showed 90.80±5.86 wound closure and tissue repair as well as significant reduction of tissue oxidative stress biomarkers. Histological analyses confirmed wound healing activity of pumpkin peel extract. Conclusion: Considering the high mucilage content of the plant, providing a moist environment for wound, C. moschata peel extract could be a natural remedy for treatment of burns. Further clinical studies are suggested to confirm C. moschata peel extract as a wound healing agent.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 17 Sep 2017 16:05
Last Modified: 17 Sep 2017 16:05
URI: http://eprints.mums.ac.ir/id/eprint/637

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