Comparison of Serum Homocystein in Abruptio Placenta and Normal Pregnancies

Arab, Malihe and Rabiee, Soghra and Pilehvari, Shamsi (2009) Comparison of Serum Homocystein in Abruptio Placenta and Normal Pregnancies. The Iranian Journal of Obstetrics, Gynecology and Infertility, 12 (4). pp. 1-6.

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Introduction: Third-trimester vaginal bleeding due to placental abruption occurs in 0.5-1 of pregnancies and is associated with 10-15 of maternal and perinatal mortality and morbidity. The etiology is unknown in most cases. Hyperhomocysteinemia is recognized as one of the independent risk factors of placental abruption. The objective of this study is to comparably measure the serum homocysteine in abruption group and normal control subjects. Methods: This case-control study is performed on 52 third- trimester pregnant women with clinical findings of abruption confirmed by after-delivery placental observation (case group) and 52 control subjects who had normal pregnancies. Samplings were done following an 8 hours of fasting. Serum homocysteine was measured with Axis R homocystein ELA kits manufactured by IBL company. Data were analyzed by chi-square and t-test. Results: It was revealed that measures like age, number of pregnancies and deliveries did not show a statistically significant difference between two groups. Mean concentration of homocysteine in abruption and control groups were 6.8±2.7 and 5.5±2.2 μmol/L, respectively (p=0.013). Conclusion: Mean serum homocystein of abruption group was higher than that of controls’. This finding may light up brand ideas for future clinical trials about reducing the serum homocysteine level and therefore, reduction of placental abruption.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 28 Sep 2017 16:13
Last Modified: 28 Sep 2017 16:13

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