Vitamin C Supplementation and PROM

Hajifoghaha, Mahboubeh and Keshavarz, Tahereh and Parsanejad, Mohammad Ebrahim and Rajaee Fard, Aboareza (2008) Vitamin C Supplementation and PROM. The Iranian Journal of Obstetrics, Gynecology and Infertility, 11 (2). pp. 33-39.

IJOGI_Volume 11_Issue 2_Pages 33-39.pdf

Download (147kB) | Preview
Official URL:


Introduction: Premature rupture of membranes (PROM) affects 10-20 of all pregnancies, occuring in approximately 30 to 40 of preterm deliveries. Vitamin C has a role in collagen metabolism and increases resistance maintenance of the chorioamniotic membranes. The objective of this study was to evaluate the relationship between vitamin C supplementation with PROM and preterm delivery. Â Methods and Materials: This clinical-trial study carried out from Jan to Jul 2006 at Hafez and Shoushtari Hospitals of Shiraz University of Medical Sciences. This study was approved by the local committee of medical ethics. Pregnant women (n=117) with 20 weeks gestational age, randomly divided into two groups 57 in the case group and 60 in the control group and evaluated every 4 weeks, from 20 to 36 weeks of pregnancy. At each evaluation, a vaginal examination was performed, to rule out bacterial vaginosis infection. The case group received a chewing tablet of 100 mg vitamin C daily. PROM and preterm delivery was recorded for each group as indicator of the protective effect of vitamin C supplementation. Â Results: PROM occurred in 5 (8.77) and 22 (36.67 ) pregnancies in the case and control group respectively (p<0/001). Four patients (7.41) in the case group and 18 pregnant women (32.08 ( in the control group delivered at term with PROM (p=0.001). One woman (33.30) in the case group and 4 women (57.10 ( in the control group delivered due to PROM at term (p> 0.5). Â Conclusion: Supplementation of vitamin C after 20 weeks of gestation prevents PROM.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 28 Sep 2017 16:57
Last Modified: 28 Sep 2017 16:57

Actions (login required)

View Item View Item