The Effect of Indomethacin Therapy on Reducing the Amniotic Fluid Index (AFI) in Moderate to Severe Polyhydramnios

Rabeie, Soghra and Rezayi, Leila (2008) The Effect of Indomethacin Therapy on Reducing the Amniotic Fluid Index (AFI) in Moderate to Severe Polyhydramnios. The Iranian Journal of Obstetrics, Gynecology and Infertility, 11 (1). pp. 55-60.

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Introduction: Severe and intermediate polyhydramnios may cause various maternal and fetal complications. Indometacin therapy in moderate to severe polyhydramnios is recommended in some studies but, there no such study has been done in Iran. This study was done in order to investigate the effect of indomethacin in decreasing AFI and on enhancing duration of pregnancy. Materials and Methods: This randomized clinical trial was carried out in the year 2006 at Hamadan Fatemieh Hospital on 40 women who were 22 to 30 weeks pregnant, suffering from moderate to sever polyhydramnios (diagnosed by sonographic examination). Patients divided randomly into two groups. Twenty patients (case group) were treated with 1/5mg/kg/day of indomethacin for two weeks and the control group were just observed and hospitalized only in case of respiratory distress or abdominal pain occurrence. patients in the case group were assessed for drug complications, then after intervention to evaluate the AFI, they were checked by sonography in the second and forth week. Both groups followed up to delivery time and neonates examined for PDA. Individual data, pregnancy duration, Apgar score, and complications were collected in the questionnaire and analyzed by SPSS software, using the descriptive statistics, frequency distribution tables and statistical tests. Statistical significance was p<0.05. Results: The mean duration of pregnancy in case and control group was 38±1.33 and 34±2.93 weeks respectively, with the statistically significant difference (p=0.0001). After 4 weeks of treatment, AFI decreased from 24.2±3.54 cm to 17.15±2.36 cm. The neonates' APGAR scores were much higher for case group in comparison with controls. Indomethacin had no maternal or fetal complications. Conclusion: This study showed that, the success rate in case group was 100. The mean duration of pregnancy was longer in case group, AFI decreased and neonates’ APGAR was better than the control group.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 28 Sep 2017 17:04
Last Modified: 28 Sep 2017 17:04

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