The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats

Jahanabadi, Samane and Hadian, Mohamad Reza and Shamsaee, Javad and Tavangar, Seyed Mohammad and Abdollahi, Alireza and Dehpour, Ahmadreza and Ejtemaei Mehr, Shahram (2016) The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats. Iranian Journal of Basic Medical Sciences, 19 (4). pp. 394-401.

[img]
Preview
Text
IJBMS_Volume 19_Issue 4_Pages 394-401.pdf

Download (510kB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_6811.html

Abstract

Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN 55,212-2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. Materials and Methods: Diabetes was induced in rats using a single dose of streptozotocin (45 mg/kg IP). Results: Intrathecal (IT) administration of WIN55, 212-2 (1, 10, 100 µg/10 µl, IT), produced antinociceptive effects in the hot plate test and also improved nerve conduction velocity (100 µg/10 µl, IT) and sciatic nerve histology. Conclusion: These data show that cannabinoids have potent antinociceptive effects through direct actions in the spinal dorsal horn of nociceptive pathway. This suggests that intrathecally administered cannabinoids may offer hopeful strategies for the treatment of diabetic neuropathic pain.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 28 Sep 2017 17:31
Last Modified: 28 Sep 2017 17:31
URI: http://eprints.mums.ac.ir/id/eprint/6560

Actions (login required)

View Item View Item