Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents

Hamedi, Shokouhsadat and Shams-Ardakani, Mohammad Reza and Sadeghpour, Omid and Amin, Gholamreza and Hajighasemali, Dawood and Orafai, Hossein (2016) Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents. Iranian Journal of Basic Medical Sciences, 19 (3). pp. 330-336.

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Abstract

Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials and Methods:Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out. Results: Discs showed excellent mucoadhesion and released high amount of the active ingredients (47) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity. Conclusion:This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn’t follow the fick’s law. The water uptake and dissolution (DS), increased with the passing of time.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 28 Sep 2017 18:13
Last Modified: 28 Sep 2017 18:13
URI: http://eprints.mums.ac.ir/id/eprint/6581

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