Incidence of thrombocytopenia and changes in various platelet parameters, in blood culture positive neonatal sepsis

Bhat, Sartaj and Naik, Suhail and Rafiq, Wasim and Tariq A, Syed (2015) Incidence of thrombocytopenia and changes in various platelet parameters, in blood culture positive neonatal sepsis. International Journal of Pediatrics, 3 (4.1). pp. 757-766.

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Abstract

Abstract Objective: To assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. Methods: This was prospective study conducted over a period of one year from December 2009 to November 2010 in neonatal intensive care unit of DDUH Hospital, a tertiary care hospital in Delhi, North India. All babies who were admitted during this period were evaluated prospectively for evidence of sepsis. Results: sepsis was diagnosed in 560 neonates. Among 560 neonates, 80/560 (14.28) had Culture positive sepsis. Out of 80 blood culture positive neonates 73 were term neonates and 7 were near term. Gram positive sepsis occurred in 21/80 (26.25), gram negative sepsis in 54/80 (67.5), and fungal sepsis in 5/80 (6.25). Incidence of thrombocytopenia in Gram negative sepsis was (35/54) 64.81, in gram positive sepsis (15/21) 71.41 and in fungal sepsis was (3/5) 60. Mean platelet count at the onset of sepsis in all the patients was 123287.5±49428.68. The mean duration of thrombocytopenia in gram positive sepsis was 4.66 ±2.6 days, in gram negative sepsis 4.39 ± 2.22 days and in fungal sepsis 5.2±1.3 days. MPV at the time of onset of sepsis (MPV) was high in gram positive sepsis than in gram negative sepsis (11.57±0.88 Vs 11.29 ± 0.76). The MPV of thrombocytopenic neonates was significantly higher than that of non-thrombocytopenic neonates (p < 0.01).

Item Type: Article
Subjects: WA Public Health
WS Pediatrics
Divisions: Journals > International J Pediatrics
Depositing User: IJP IJP
Date Deposited: 28 Sep 2017 23:40
Last Modified: 28 Sep 2017 23:40
URI: http://eprints.mums.ac.ir/id/eprint/6618

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