The effect of mesoporous silica nanoparticles loaded with epirubicin on drug-resistant cancer cells

Hanafi-Bojd, Mohammad Yahya and Ansari, Legha and Mosaffa, Fatemeh and Malaekeh-Nikouei, Bizhan (2017) The effect of mesoporous silica nanoparticles loaded with epirubicin on drug-resistant cancer cells. Nanomedicine Journal, 4 (3). pp. 135-141.

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Abstract

Objective (s): In chemotherapy for cancer treatment, the cell resistance to multiple anticancer drugs is the major clinical problem. In the present study, mesoporous silica nanoparticles (MSNs) were used as a carrier for epirubicin (EPI) in order to improve the cytotoxic efficacy of this drug against the P-glycoprotein (P-gp) overexpressing cell line. Materials and Methods: MSNs with phosphonate groups were synthesized and characterized. The cytotoxicity of the prepared nanoparticles on drug-sensitive human breast cancer cell line (MCF-7) and drug-resistant cancer cells (MCF-7/ADR) was evaluated. Results: The hydrodynamic size of nanoparticles was 98 nm and surface charge was negative. The viability of sensitive MCF-7 and resistant MCF-7/ADR cells after incubation with MSNs containing EPI at concentration of 5 μg/ml was about 75 and 44. On the other hand, the viability of sensitive and resistant cells after incubation with free EPI at this concentration was about 48 and 60, respectively. Conclusion: These nanoparticles exhibited suitable drug efficiencies against drug-resistant MCF-7/ADR cells in vitro experiments.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Nanomedicine Journal
Depositing User: nmj nmj
Date Deposited: 17 Sep 2017 16:44
Last Modified: 17 Sep 2017 16:44
URI: http://eprints.mums.ac.ir/id/eprint/664

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