Significant roles played by interleukin-10 in outcome of pregnancy

Mobini, Masoud and Mortazavi, Maryam and Nadi, Somayeh and Zare-Bidaki, Mohammad and Pourtalebi, Somayeh and Kazemi Arababadi, Mohammad (2016) Significant roles played by interleukin-10 in outcome of pregnancy. Iranian Journal of Basic Medical Sciences, 19 (2). pp. 119-124.

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Abstract

Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-10(IL-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-10 during pregnancy may result in several pathologic conditions such as preterm labor. IL-10 leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, T regulatory lymphocytes and activation of the JAK1/STAT3 pathway in the target cells. This review has collected recent data regarding the status of IL-10 expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 29 Sep 2017 02:47
Last Modified: 29 Sep 2017 02:47
URI: http://eprints.mums.ac.ir/id/eprint/6641

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