Core-shell magnetic pH-responsive vehicle for delivery of poorly water-soluble rosuvastatin

Amoli-Diva, Mitra and Pourghazi, Kamyar (2017) Core-shell magnetic pH-responsive vehicle for delivery of poorly water-soluble rosuvastatin. Nanomedicine Journal, 4 (3). pp. 142-151.

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Abstract

Objective(s): Development of an oral sustained-controlled release vehicle which, slowly releases the drug and maintains an effective drug concentration for a long time is aimed.Materials and Methods: A biodegradable magnetic polymeric drug delivery vehicle, using superparamagnetic iron oxide nanoparticles encapsulating by polyvinylpyrrolidone-block-polyethylene glycol-block-poly methacrylic acid (PVP-PEG-PMAA) was developed for targeted and controlled delivery of rosuvastatin. The carrier was characterized by TEM, XRD, and FT-IR techniques.Results: A typical carrier has about a 9 nm magnetite core, about 20 nm mean diameter with a narrow size distribution. The loading efficiency and pH-controlled release properties of the carrier were examined using a hydrophobic model drug rosuvastatin. Maximum loading efficiency of about 96 and a release amount of 90 of 12 hours were achieved at 37 oC in pH 1.2. While in pH 5.5 and 7.2, release amount of 25 and 37 were obtained respectively.Conclusion: The results indicate that the prepared pH-responsive polymer which covalently coated around magnetic nanoparticles is an efficient carrier with good loading capacity and controlled-release property.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Nanomedicine Journal
Depositing User: nmj nmj
Date Deposited: 17 Sep 2017 16:58
Last Modified: 17 Sep 2017 16:58
URI: http://eprints.mums.ac.ir/id/eprint/665

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