Improvement effect of Lycium barbarum polysaccharide on sub-health mice

Zhao, Rui and Hao, Wenli and Ma, Baoling and Chen, Zhibao (2015) Improvement effect of Lycium barbarum polysaccharide on sub-health mice. Iranian Journal of Basic Medical Sciences, 18 (12). pp. 1245-1252.

IJBMS_Volume 18_Issue 12_Pages 1245-1252.pdf

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Objective(s):Sub-health has been described as a chronic condition of unexplained deteriorated physiological function, which falls between health and illness. In the present study, we evaluated the effects of Lycium barbarum polysaccharide (LBP), a polysaccharide fraction purified from Lycium barbarum (L. barbarum) on the sub-health mice. Materials and Methods:The sub-health model mice were built through compound factors. The mice were given intragastric administration of LBP at low dose (50 mg•kg-1) and high dose (100 mg•kg-1), respectively. After LBP treatment for 4 weeks, the antioxidant ability, enhancing immune function and anti-fatigue activity were detected. Results:The results showed that LBP could enhance antioxidant ability in sub-health mice. LBP could effectively improve immunity of sub-health mice and protect the immune organs, such as thymus. In addition, LBP showed anti-fatigue ability in sub-health mice. Conclusion:LBP could improve sub-health state caused from composite factor through three aspects, such as increasing antioxidant ability, promoting T lymphocyte proliferation, inhibiting thymus lymphocyte apoptosis, and alleviating fatigue.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 02 Oct 2017 13:23
Last Modified: 02 Oct 2017 13:23

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