Osteoporosis after stem cell transplantation

Khalesi, Maryam and Beiraghi Toosi, Mehran (2014) Osteoporosis after stem cell transplantation. International Journal of Pediatrics, 2 (2.3). p. 48.

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Background Stem cell transplantation has become as a novel treatment for end-stage kidney, lung, heart , liver diseases and several hematologic disorders. Improved survival of transplant recipients has raised awareness of post-transplant complications. One of these complications is transplant-related osteoporosis. Methods In this manuscript we review prevention methods for transplant-related osteoporosis according to the literature. Results Transplant-related osteoporosis is due to both pre-transplant and post-transplant factors. The most common pre-transplant factor is low bone mineral density related to the underlying disease. The most common post-transplant factor is consumption of immunosuppressive regimens. Bone loss is most rapid in the first 6 to 12 months after transplantation with subsequent slowing thereafter, due to a reduction in immunosuppressive dose and resolution of pretransplant conditions that were deleterious to skeletal health. For prevention of this problem it is recomm ended to measurement of bone mineral density before transplantation. Also all patients should receive counseling about quit smoking, early mobilization after transplantation, regular weight-bearing exercise and fall prevention. Patients should receive 1000 mg/day of calcium and 800 units/day of vitamin D before transplantation. Higher vitamin D doses should be given for patient with vitamin D deficiency. The lowest prednisone dose compatible with graft survival is recommended. Conclusion It is necessary to consider preventive measures for reduce transplant-related osteoporosis. Keywords: Osteoporosis, Stem cell, Transplantation.

Item Type: Article
Subjects: WA Public Health
WS Pediatrics
Divisions: Journals > International J Pediatrics
Depositing User: IJP IJP
Date Deposited: 30 Sep 2017 00:42
Last Modified: 30 Sep 2017 00:42
URI: http://eprints.mums.ac.ir/id/eprint/6887

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