Comparing the effect of flaxseed oil with vitamin E on non-invasive markers of liver in patients with nonalcoholic fatty liver disease

Beheshti Namdar, Ali and Bahari, Ali and vosughinia, Hasan and saadatnia, Hasan and Esmaeelzade, Abbas and Ganji, Azita and Ghanaii, Omid and Sheikhian, Mohammadreza and Amiri Moghadam, Shirin (2015) Comparing the effect of flaxseed oil with vitamin E on non-invasive markers of liver in patients with nonalcoholic fatty liver disease. medical journal of mashhad university of medical sciences, 57 (8). pp. 890-897.

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Abstract

Introduction  Omega-3 polyunsaturated fatty acids have proven effects on hyperlipidemia and cardiovascular diseases. Given that there is no single consensus on the treatment of NAFLD and high levels of Omega-3 is found in flax seed oil and in this regard no study has been done in the world, we decided to evaluate the effects of flaxseed oil on non-invasive markers of fatty liver . Material and Methods  In a randomised controlled trial, 60 participants with NAFLD were randomised to 2 months treatment with either Flaxseed or vitamin E(in two groups each 30).Weight, body mass index, waist circumference, liver enzymes, blood glucose, insulin and lipid profiles were measured before and after the intervention.  Results In flax seed oil group ALT, AST, ALP (alkaline phosphatase)., TG (triglyceride)., Insulin was decreased and HDL (High density lipoprotein). Were  increased significantly(P<0.05)..In vitamin E group, only the level of AST, ALT and total bilirubin was significantly decreased. (P<0.05).  Conclusion Flaxseed oil is effective and safe in the improvement of non-invasive liver markers of patients with NAFLD. However, further studies with a larger sample size are needed to confirm the efficacy and safety of this drug.  Acknowledgment :This is no conflict of interest

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 01 Oct 2017 02:11
Last Modified: 01 Oct 2017 02:11
URI: http://eprints.mums.ac.ir/id/eprint/6987

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