Comparison Efficacy of Doxycycline and Azithromycin and Clarithromycin in the Treatment of Chronic Bacterial Rhinosinusitis

Farokhpey, Farhad and Niabati, Niloofar and Amri Maleh, Mohamad and Omraninava, Melodi and Mansoursaravi, Mohammad and Amri Maleh, Parviz (2014) Comparison Efficacy of Doxycycline and Azithromycin and Clarithromycin in the Treatment of Chronic Bacterial Rhinosinusitis. medical journal of mashhad university of medical sciences, 57 (7). pp. 814-821.

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Introduction: Chronic sinusitis is one of the most common causes of referring to physician and creates longterm discomfort for people. The common bacterial organisms include: Streptococcus pneumonia, Hemophillous influenza, Moraxella catarrhalis, Staphylococcus aurous, biofilm and superantigen produced by some of these bacteria should be considered. This study aimed to compare the efficacy of Doxycycline, Azithromycin and Clarithromycin in the treatment of chronic bacterial rhinosinusitis. Materials and Methods: In this clinical trial, 55 patients with a mean age of 36 years with chronic bacterial rhinosinusitis who were documented clinically and by imaging (CT Scan), were treated in three groups with Doxycycline (100mg BD), Azithromycin (8mg/kg BD), and Clarithromycin (500mg BD). The patients were followed by clinical signs, symptoms and imaging. Data were analyzed by SPSS software and Chi Square, Anova and T test. Results: At the end of treatment, Doxycycline�s treatment success rate was higher than Azithromycin and Clarithromycin (the clinical cure rates respectively were 73 versus 57 and 40, and CT Scan cure rate results respectively were 70 versus 33 and 25). Conclusion: The results of present study indicated that the Doxycycline in the treatment of chronic bacterial rhinosinusitis was more effective than Azithromycin and Clarithromycin in clinical response and improved CT Scan results. Acknowledgment: Thanks to Mr. Bahrami for data analysis, Mr.Einollah Alipur, Ms. Darwish to collect samples , the University of Medical Sciences and the staff of CT Scan ,Shahid Rajaee &Emam Sajjad Hospital  clinics of Ramsar for the necessary cooperation in this research project.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 02 Oct 2017 14:30
Last Modified: 02 Oct 2017 14:30

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