The effect of L-carnitin supplementation on hyperlipidemia in pediatric nephrotic syndrome

Esmaeili, Mohammad and Esmaeili, Marjan and Ghane, Fatemeh and Azarfar, Anoush (2014) The effect of L-carnitin supplementation on hyperlipidemia in pediatric nephrotic syndrome. medical journal of mashhad university of medical sciences, 57 (7). pp. 859-865.

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Abstract

Introduction: Hyperlipidemia is a major risk factor for atherosclerosis and cardiovascular incidents. Abnormalities in lipoproteins and lipids profile are common in patients with pediatric idiopathic nephrotic syndrome and may contribute to atherosclerosis. Prescription of lipid lowering agents such as statins because of myopathy and growth disorders, are not recommended in child-aged groups. However, there isn�t any investigation on carnitine effects on lipids profile of patients with childhood nephrotic syndrome which is the propose of our study. Materials and Methods: In this case-control study, case group included 16 patients in 2-12 years of age with steroid resistant nephrotic syndrome, receiving prednisolon, cyclosporine and  carnitine (25mg/kg/day) within a 3 months period and control group included 17 age and sex matched patients, receiving standard treatment (prednisolon, cyclosporine), were compared. In both groups, biochemical parameters like triglyceride, cholesterol, VLDL, LDL, HDL, BUN, creatinine and serum albumin were measured. Results: At the end of the study period, L-carnitine treated group showed no significant difference in the biochemical markers compared with the control group (P-values>0.05). Conclusion: Our study indicates that oral administrations of L-carnitine with the dose of 25 mg/kg/day did not have any effects on lipoprotein profile of persistent childhood nephrotic syndrome. Acknowledgement: This study was supported by a grant from the Vice chancellor for research of the Mashhad University of Medical Sciences for the research project as a medical student thesis with approval number of 87718. We would like to thank Dr. Naser Shoeibi for statistical analysis and Ms. Saeide seyed hoseini for typing of the manuscript.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 02 Oct 2017 14:38
Last Modified: 02 Oct 2017 14:38
URI: http://eprints.mums.ac.ir/id/eprint/7036

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