Treatment of fibrous dysplasia with Bisphosphonates

Vakili, Rahim and Gharahdaghi, Mohammad and Kouzegaran, Samaneh (2014) Treatment of fibrous dysplasia with Bisphosphonates. medical journal of mashhad university of medical sciences, 57 (7). pp. 874-878.

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Abstract

Introduction: Fibrous dysplasia is a benign skeletal lesion. It is related to McCune-Albright syndrome with patchy cutaneous pigmentation. Recent trials in pediatric patients with fibrous dysplasia have shown encouraging results. Bisphosphonate therapy may help to improve function, decrease pain, and lower fracture risk in appropriate selected patients. Index patient, a 12-year-old girl with history of limping and bone pain for 2 years that had no response to common treatment. After more evaluation, she referred to pediatric endocrinology department with the diagnosis of fibrous dysplasia and was treated using periodic intravenous pamidronate every three month. She showed good outcome and symptomatic improvement over 6 month duration of fallow up. Conclusion: Recent trials in pediatric patients with fibrous dysplasia have shown encouraging results. In our patient treatment with periodic intravenous infusion of pamidronate resulted in an improvement of pain and limping without important side effects.  Acknowledgement: We would like to thank Radiology and laboratory department of Imam Reza hospital. Conflict of Interest: None

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 02 Oct 2017 14:40
Last Modified: 02 Oct 2017 14:40
URI: http://eprints.mums.ac.ir/id/eprint/7038

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