Comparison of the hemodynamic effects of Etomidate versus propofol, Rapid Sequence Intubation, on none surgical patients

Moosavi Tekye, Seyyed Mostafa and Pashang, Seyyed Mostafa (2014) Comparison of the hemodynamic effects of Etomidate versus propofol, Rapid Sequence Intubation, on none surgical patients. medical journal of mashhad university of medical sciences, 57 (4). pp. 602-608.

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Abstract

Introduction Rapid sequence intubation is planned to protect airway from aspiration and keep patient's ventilation in critically ill cases. Intubation need a sedative drug that has the least hemodynamic instability effect and complications. This prospective-randomized study compared the hemodynamic effects of Etomidate and propofol during Rapid sequence Intubation on non surgical patients. Materials & Methods Critically ill patients with ASA III, IV who needed rapid sequence intubation were divided into two groups of 47 patients. Patients first sedated with 2µ/kg fentanyl and ventilated with bag and mask (sellick's maneouvre). In group 1 1mg/kg propofol and in group 2 0.3 mg/kg etomidate were injected.Vital signs and oxygen saturation were recorded before and five minutes after intubation. Results Demographic data were similar in two groups. Systolic and diastolic blood pressure, heart rate and oxygen saturation were similar in two groups before intubation, but five minutes after intubation hemodynamic changes were less in etomidate group (p=0.000, p=0.000, p=0.047, p=0.004 respectively). Conclusion Usage of etomidate for sedation in rapid sequence intubation had better hemodynamic stability effect than propofol.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 02 Oct 2017 15:04
Last Modified: 02 Oct 2017 15:04
URI: http://eprints.mums.ac.ir/id/eprint/7074

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