Correlation of Serum Total and Free Testosterone Levels with Hemoglobin and High Sensitive CRP in Patients with Chronic Kidney Disease in Third and Fourth Stages and Hemodialysis patients

Layegh, Parvin and Zeraati, Abbas Ali and Rastgoo, Neda and Naghibi, Massih and Sharifipour, Farzaneh and Afkhamizadeh, Mojgan and Mamdouhi, Fereshteh (2014) Correlation of Serum Total and Free Testosterone Levels with Hemoglobin and High Sensitive CRP in Patients with Chronic Kidney Disease in Third and Fourth Stages and Hemodialysis patients. medical journal of mashhad university of medical sciences, 57 (2). pp. 480-485.

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Abstract

Introduction: There is strong clinical and experimental data that testosterone stimulates erythropoiesis. Inflammation, on the other hand, significantly impacts on haemopoiesis, partly through its suppression of erythropoietin and partly through its direct action on erythropoiesis. Therefore, in this study we evaluated correlation of serum testosterone levels with hemoglobin (Hb) and high sensitive CRP (hs-CRP) in patients with Chronic Kidney Disease (CKD (in third and fourth stages and hemodialysis patients. Materials and Methods: A total of 29 patients with CKD in third and fourth stages (group1) and 29 hemodialysis patients (group 2) were included in this study. Serum hs-CRP, Hb, total and free testosterone, LH, FSH and erythropoietin levels were measured. Pearson`s correlation analysis was used for determining correlation between variables. Results:The mean of serum hs-CRP level was significantly lower in group1 than group 2, while serum FSH was significantly higher in group1. Pearson`s correlation analysis showed a significant positive correlation between hs-CRP and LH in total patients in two groups and patients in group 2. In comparison among 4 groups including  group 1 and 2 with (HgbConclusion: The significant inverse correlation between hs-CRP and total testosterone in hemodialysis patients with Hb lower than 11gr/dl suggested that this association may also partly contribute to anemia in hemodialysis patients compared with CKD patients in third and fourth stages.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 02 Oct 2017 15:35
Last Modified: 02 Oct 2017 15:35
URI: http://eprints.mums.ac.ir/id/eprint/7098

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