Antinociceptive action of Vanillosmopsis arborea in male mice

Inocencio Leite, Laura and Leite, Gerlânia de Oliveira and Fernandes Silva, Bruno Anderson and Sousa, Severino Denício Gonçalves and Coutinho, Thales and Sampaio, Renata and Menezes, Irwin and Martins Costa, José Galberto and Campos, Adriana (2017) Antinociceptive action of Vanillosmopsis arborea in male mice. Avicenna Journal of Phytomedicine, 7 (1). pp. 93-98.

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Abstract

Objective: Vanillosmopsis arborea Baker (Asteraceae) has high economic value from Chapada to Araripe and its bark essential oil is a potential source of alpha-bisabolol. The present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil of V. arborea Baker (EOVA) in mice. Materials and Methods: The antinociceptive activity was assessed using the capsaicin, glutamate, hot plate and cold allodynia tests. The antipuritic effects were also verified based on histamine-induced scratching behavior. Results: EOVA reduced the paw licking induced by capsaicin, but not that induced by glutamate. The essential oil increased the latency time in the hot plate, attenuated the cold allodynia induced by acetone and inhibited histamine-induced scratching behavior. Conclusion: The experimental data demonstrated that EOVA showed central and peripheral antinociceptive activity and antipruritic effect.

Item Type: Article
Subjects: WH Hemic and Lymphatic System
QY Clinical Pathology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 18 Sep 2017 12:42
Last Modified: 18 Sep 2017 12:42
URI: http://eprints.mums.ac.ir/id/eprint/711

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