Opium Addiction as a Cause of Gastroduodenal Reflux in Dyspeptic Patients

Bahari, Ali and Izadi, Shahrokh and Heirani Moghadam, Hamid and Saneie Moghadam, Amin (2012) Opium Addiction as a Cause of Gastroduodenal Reflux in Dyspeptic Patients. medical journal of mashhad university of medical sciences, 55 (1). pp. 21-27.

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Introduction Drug abuse as a frequent high risk behavior accompanies many different gastrointestinal complications. In this study we tried to evaluate the prevalence of gastrointestinal reflux among opium addicts. Materials and Methods Using a historical cohort design, 62 cases with dyspepsia as the chief complaint entered the study: 30 cases with history of regular use of opium over the last year (exposed group) and 32 cases with no history of addiction at all (unexposed group). Upper GI tract endoscopy was accompanied by 3 biopsy specimens taken from body and antre of stomach was performed for all the cases. Results 2 cases in the exposed group and 3 cases in the unexposed group left the study with the diagnosis of malignancy. Mean age of the remaining cases in the exposed group was 48.1±13.2 and in the unexposed group, it was 37.8±13.9 years (p= 0.006). 16 cases (57.1) in the exposed group and 5 cases (17.2) in the unexposed group had endoscopic evidence of bile reflux into the stomach (p= 0.003). Pathologic evidence of bile gastritis including foveolar elongation was reported in 7 cases (25.0) of the exposed group in comparison with 1 case (3.4) of the unexposed group (p = 0.025). The frequency of

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 02 Oct 2017 16:49
Last Modified: 02 Oct 2017 16:49
URI: http://eprints.mums.ac.ir/id/eprint/7196

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