Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design

Enayatifard, Reza and Mahjoob, Aiding and Ebrahimi, Pouneh and Ebrahimnejad, Pedram (2015) Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design. Iranian Journal of Basic Medical Sciences, 18 (7). pp. 710-714.

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Abstract

Objective(s): A Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design. Materials and Methods: Diclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of plasticizer level, curing temperature and curing time was determined on the release of diclofenac from pellets coated with polymethacrylates. Results: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release. The optimization process generated an optimum of 35 drug release at 3 hr. The level of plasticizer concentration, curing temperature and time were 20 w/w, 55 °C and 24 hr, respectively. Conclusion: This study showed that by controllinig the physical variables optimum drug release were obtained.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 02 Oct 2017 23:38
Last Modified: 02 Oct 2017 23:38
URI: http://eprints.mums.ac.ir/id/eprint/7334

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