Association study of four polymorphisms in the interleukin-7 receptor alpha gene with multiple sclerosis in Eastern Iran

Sadeghi Haj, Mehrdad and Nikravesh, Abbas and Pahlevan Kakhki, Majid and Rakhshi, Nahid (2015) Association study of four polymorphisms in the interleukin-7 receptor alpha gene with multiple sclerosis in Eastern Iran. Iranian Journal of Basic Medical Sciences, 18 (6). pp. 593-598.

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Abstract

Objective(s): Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) with unknown etiology. Various genetics and environmental factors contribute to the pathogenesis of the disease. The interleukin-7 receptor alpha chain (IL-7Ra) was identified as the first non-major histocompatibility complex (non-MHC) MS susceptibility locus. In this study we are trying to find the association of IL-7Ragene polymorphisms with MS susceptibility in Eastern Iran. Materials and Methods:A case-control study was performed in two provinces Sistan & Baluchistan and Khorasan with 219 patients and 258 unrelated matched healthy controls, using PCR-RFLP method for four single nucleotide polymorphisms (SNPs) rs7718919, rs11567685, rs11567686 and rs6897932 of IL-7Ra gene. Results:We found a tendency toward association with genotyping analyses in SNP rs7718919 (P=0.048, OR=4.344, and 95 CI=0.892-21.146); also genotype and allele frequency in gender and MS subtype stratification were shown to have significant association with MS. Analysis of two provinces separately showed a significant difference in results of the allele and genotype frequencies. Moreover, haplotyping analysis showed that (GTGC) has an association only in the male secondary-progressive multiple sclerosis (SPMS) patients in comparison to the healthy controls (P=0.043, OR=0.413, and 95 CI=0.179–0.955). Conclusion:IL7-Ra could be a susceptible gene to MS within the Eastern Iran population especially after MS and gender stratification.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 03 Oct 2017 12:57
Last Modified: 03 Oct 2017 12:57
URI: http://eprints.mums.ac.ir/id/eprint/7345

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