Serum Levels of Cyfra 21 in Patients with Benign and Malignant Salivary Gland Tumors

Jeiroodi, Naghmeh and Aslani, Seyed Mohammad- Javad and Khademi, Bijan and Malekzadeh, Mahyar and Jaafari- Ashkavandi, Zohreh (2017) Serum Levels of Cyfra 21 in Patients with Benign and Malignant Salivary Gland Tumors. Iranian Journal of Otorhinolaryngology, 29 (4). pp. 203-208.

IJORL_Volume 29_Issue 4_Pages 203-208.pdf

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Introduction: Cyfra 21 is a serum-soluble fragment of cytokeratin19. Increased Cyfra 21 serum levels and their benefit as a tumor marker have been shown in some malignancies. This study aimed to evaluate the serum levels of Cyfra 21 in patients with benign and malignant salivary gland tumors. Materials and Methods: In this cross-sectional study, the serum level of Cyfra 21 in 44 patients with malignant salivary gland tumors and 16 cases of pleomorphic adenoma were compared with 28 healthy controls using enzyme-linked immunosorbent assay (ELISA). Data were analyzed statistically using the Kruskal Wallis test, analysis of variance (ANOVA) and Spearman's correlation tests. Results: Mean serum levels of Cyfra 21 were 0.135 ± 0.285 ng/ ml in the control group, 0.167 ± 0.142 ng/ ml in patients with pleomorphic adenoma and 1.059 ± 3.251 ng/ml in patients with malignant salivary gland tumors. There was no significant difference among groups. Cyfra 21 levels did not correlate with location of tumor, clinical stage or cigarette smoking. Conclusion: Results of the present study showed no significant difference in Cyfra 21 serum level in salivary gland tumors compared with normal individuals. In addition, Cyfra 21 serum level was not sufficiently sensitive to function as a tumor marker in salivary gland tumors.

Item Type: Article
Subjects: WV Otolaryngology
Divisions: Journals > Iranian J Otorhinolaryngology
Depositing User: ijo ijo
Date Deposited: 18 Sep 2017 13:48
Last Modified: 18 Sep 2017 13:48

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