Effects of knotweet or polygonum aviculare herbal extract on proliferation of HeLa cell line

Banazadeh, Hossein and Delazar, Abbas and Habibi Roudkenar, Mehryar and Rahmati Yamchi, Mohammad and Sadeghzadeh Oscoui, Behnaz and Mehdipour, Ahmad and Soleimani Rad, Jafar and Mohammadi Roushandeh, Amaneh (2011) Effects of knotweet or polygonum aviculare herbal extract on proliferation of HeLa cell line. medical journal of mashhad university of medical sciences, 54 (4). pp. 238-241.

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Introduction  Cervical cancer is the most common cancer in women living in developing countries. Recently, for treatment of diseases such as cancer, herbal medicine is used as a supplementary.The Aim of this study was assessment of anticancerous effects of polygonum aviculare herbal extract on Hela cervical cancer cell line Materials and Methods HeLa cells were cultured in RPMI -1640 with 10 Fetal Bovine Serum in 5 Co2 and at 37ºC in different concentrations (0, 0.005, 0.05, 0.01, 0.025, 0.075, 0.1, 0.125, 0.15, 0.175, 0.2, 0.25, 0.3, 0.35, 0.5, 5 mg/ml) of polygonum aviculare. For assessment of viability of cells, trypan blue staining was performed. MTT assay was used for proliferation detection. Results: our results showed that in 0.15, 0.20 and 0.35 mg/ml proliferation of HeLa cells decreased according to MTT assay. Conclusion It was proved that polygonum aviculare had antioxidant component and could be a scavenger of free radical. Because of high production of free radicals in diseases such as cancer, the use of the herbal medicine with high amount of antioxidant could be a supplementary treatment in cancer and other diseases.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 14:36
Last Modified: 03 Oct 2017 14:36
URI: http://eprints.mums.ac.ir/id/eprint/7373

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