Alpha-lipoic acid loaded in chitosan conduit enhances sciatic nerve regeneration in rat

Azizi, Saeed and Hamidi Alamdari, Daryoush and Amini, Keyvan and Raisi, Abbas and Azimzadeh, Mohammad (2015) Alpha-lipoic acid loaded in chitosan conduit enhances sciatic nerve regeneration in rat. Iranian Journal of Basic Medical Sciences, 18 (3). pp. 228-233.

[img]
Preview
Text
IJBMS_Volume 18_Issue 3_Pages 228-233.pdf

Download (1MB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_4120.html

Abstract

Objective(s): To investigate the effect of topical administration of alpha-lipoic acid into chitosan conduit on peripheral nerve regeneration using a rat sciatic nerve transection model. Materials and Methods: Forty five Wistar rats were divided into three experimental groups randomly. A 10-mm gap of sciatic nerve was bridged with a chitosan conduit following surgical preparation and anesthesia. In treatment group, the conduit was filled with 30 µl alpha-lipoic acid (10 mg/kg/bw).It was filled with 30 µl phosphate buffered saline solution in control group. In Sham group sciatic nerve was just exposed. Results: The recovery of nerve function was faster in treatment group than in control, at 4 and 8 weeks after surgery (P-value<0.05). Conduction velocity was better in treatment group than in control group at 4 and 12 weeks (P-value<0.05). Recovery index was higher in treatment group than the control group, 8 weeks after surgery (P-value <0.05). Greater nerve fiber diameter, axon diameter, and myelin sheath thickness were observed in treatment group compared to control group at 8 and 12 weeks after surgery (P-value<0.05). The immunoreactivity of regenerated axons and myelin sheath in treatment group were far more similar to sham group. Conclusion: Alpha-lipoic acid when loaded in a chitosan conduit could improve transected sciatic nerve regeneration in rat.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 03 Oct 2017 16:02
Last Modified: 03 Oct 2017 16:02
URI: http://eprints.mums.ac.ir/id/eprint/7399

Actions (login required)

View Item View Item