The Study on Fungal Colonization of Respiratory Tract in Patients Admitted to Intensive Care Units of Sari and Babol hospitals

Khodavaisy, Sadegh and Alialy, Masoud and Mahdavi Omran, Saeed and Habibi, Mohammad Reza and Amri, Parviz and Monadi, Mahmoud and Hedayati, Mohammad Taghi (2011) The Study on Fungal Colonization of Respiratory Tract in Patients Admitted to Intensive Care Units of Sari and Babol hospitals. medical journal of mashhad university of medical sciences, 54 (3). pp. 177-184.

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Introduction  Fungi are considered as a life threatening in immunocompromised patients and respiratory tract is the main involvement location. Critically ill patients who are admitted to intensive care units (ICU) may also be susceptible to these infections, because of their conditions. Fungal colonization in respiratory tract maybe consider as a probable source for infection. Therefore, in the present study we evaluatedfungal flora of respiratory tract in patients admitted to ICU. Materials and Methods Bronchoalveolar lavage samples were collected by bronchoscope from 45 patients with underlying predisposing conditions for invasive fungal infection twice a week. Samples were homogenated by pancreatin for performance of direct microscopic examination and cultured on Sabouraud�s dextrose agar. The grown fungi on culture media were identified by standard mycological procedures. Results The main underlying predisposing conditions were COPD (22.2), hematologic malignancy (20.3) and prolonged stay in the ICU (16.9). The mean length of ICU stay was 19.6 days. Overall, 80 samples had positive result in direct examination (76.2) and culture (71.2), respectively. The most frequent isolated fungi were Candida (64.7), Aspergillus (19.3) and Penicillium (7.9). Among Candida and Aspergillus species, C. albicans and A. flavus were most common. In 48.4 of patients, similar fungal species were isolated in both sampling times. Conclusion The results of our study showed that the ICU patients were susceptible to fungal resistant colonization especially Candida and Aspergillus as two life threatening fungal agents. So we emphasize the control procedures to reduce the fungal infection possibility among ICU patients.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 16:35
Last Modified: 03 Oct 2017 16:35

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