Diagnostic Accuracy of Helicobacter Stool Antigen in Dyspeptic Patients before Eradication Therapy

Amoueian, Sakineh and Moradi moghadam, Farideh and Esmailzadeh, Abbas and Attaranzadeh, Armin and Rahimi, Mehdi and Montazer, Mehdi (2011) Diagnostic Accuracy of Helicobacter Stool Antigen in Dyspeptic Patients before Eradication Therapy. medical journal of mashhad university of medical sciences, 54 (1). pp. 13-18.

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Abstract

Introduction The aim of this study was to assess and compare the diagnostic accuracy of Helicobacter pylori stool antigen (HpSA) test with three other invasive and non-invasive diagnostic methods. Materials and Methods A total of Fifty-two dyspeptic patients were included. None of the patients had previous eradication therapy for Helicobacter pylori. Endoscopic biopsy samples were obtained for histology examination and Rapid Urease Test (RUT). Urea Breath Test (UBT) and HpSA were also performed. Patients were considered Helicobacter pylori positive when 2 of 3 tests (histology examination, RUT and UBT) were positive (gold standard). Diagnostic accuracy of HpSA was assessed performing a Receiver Operating Curve (ROC) analysis. Results Twenty-threeWere men and 29Were women, with a mean age of 42.3 years of the Palients.The prevalence of Helicobacter pylori infection was 67.3. ROC curve analysis was showed a significant area under curve of 94.6 (p=0.0001). Cut-off value was estimated to be 0.1. The sensitivity, specificity, positive and negative predictive values of HpSA was 91.4, 94.1, 97 and 84, respectively. HpSA level significantly increased with increasing in bacterial load. Conclusion HpSA was proved to be a highly accurate, simple and non-invasive test for the diagnosis of Helicobacter pylori infection before treatment in dyspeptic patients.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 17:27
Last Modified: 03 Oct 2017 17:27
URI: http://eprints.mums.ac.ir/id/eprint/7442

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