Comparison of Diagnostic Value of Fasting Plasma Glucose with 100 Gram Oral Glucose Tolerance Test in Gestational Diabetes Mellitus Screening

Mirfeizi, Mani and Asghari jafarabadi, Mohamad and Shoghi, Mahnaz (2011) Comparison of Diagnostic Value of Fasting Plasma Glucose with 100 Gram Oral Glucose Tolerance Test in Gestational Diabetes Mellitus Screening. medical journal of mashhad university of medical sciences, 54 (1). pp. 38-43.

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Abstract

Introduction Many different tests have been introduced for screening of gestational diabetes mellitus (GDM).The Objectives of this study were comparison of diagnostic value of fasting plasma glucose (FPG) with 100 gram oral glucose tolerance test (OGTT) and determining the suitable cut-off point of plasma glucose with best sensitivity and specificity for diagnosis of gestational diabetes mellitus (GDM). Materials and Methods This study was a clinical trial and Carried out on 242 women in Karaj-Iran. After doing 50 gram glucose challenge test (GCT), if 1-hour plasma glucose was �130 mg/dl, the 3 hours 100 gram OGTT was performed. The diagnostic values of FPG and 1, 2 and 3 hours plasma glucose were compared by receiver operating characteristic curve (ROC). Results Overall 50 gram GCT was positive in 41/3. Then 100 gram OGTT for these was performed, 36 were identified as GDM. With using below surface of ROC curve for FPG (o/75), 1-hour (0/87), 2-hour (0/95) and 3-hour (0/75) plasma glucose determined that FPG with cut-off point �91 mg/dl had 63.89 sensitivity rate and 76/56 specificity rate for diagnosis of GDM. However, 2-hour plasma glucose with cut-off point �153 mg/dl had highest level of sensitivity rate (91/67) and specificity rate (89/06). Conclusion Two-hour glucose with cut-off point �153 mg/dl had the best sensitivity and specificity rate in diagnosis of GDM. Therefore, 100 gram OGTT recommended for screening of GDM.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 17:34
Last Modified: 03 Oct 2017 17:34
URI: http://eprints.mums.ac.ir/id/eprint/7446

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