A Comparative Immunohisto chemical Diagnosis of Hodgkin�s lymphoma with Conventional Method

Mirsadraee, Saadat and Farzadnia, Mehdi and Heidary, Fateme and Rahimi, Mahdi and Jabbari Noghabi, Hadi and Kakhi, Sorayya (2010) A Comparative Immunohisto chemical Diagnosis of Hodgkin�s lymphoma with Conventional Method. medical journal of mashhad university of medical sciences, 53 (4). pp. 214-221.

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Introduction Hodgkin�s lymphoma is a malignant neoplasm of B lymphocytes and less common T lymphocytes that morphologically can be mistaken with several benign and malignant diseases. These diseases have different course, treatments and prognosis from Hodgkin�s lymphoma. Immunohistochemical staining is very useful that will aid in separating Hodgkin�s Lymphoma from a series of benign and malignant lookalikes. Materials and Methods We Randomly selected 53 cases with primary diagnosis of Hodgkin�s lymphoma in pathology laboratory of Imam Reza Hospital from 1374-1384. to confirm or rule out of the primary diagnosis, microscopic evaluation and Immunohistochemical staining were done. Results Overall in 47 cases (88.7), Hodgkin�s lymphoma was confirmed and 6 cases (11.3) were non hodgkin lymphoma.A total 5 cases were T cell Rich large B cell lymphoma and 1 case was anaplasic large cell lymphoma probably. In Hodgkin�s lymphoma cases, the mean age was 40 years. Except for nodular sclerosis other types were more frequent in males. (M/F = 2.5).The commonest type was mixed cellularity (39 cases) (54.7). Conclusion Misdiagnosis of Hodgkin�s lymphoma without Immunohistochemical staining was 11.3. Because of significant difference between treatment and prognosis of Hodgkin�s lymphoma and other morphologically similar diseases, immunohistochemical staining particulary in lymphocytic depletion and nodular lymphocytic predominant Hodgkin�s lymphoma, is necessary and recommended.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 17:46
Last Modified: 03 Oct 2017 17:46
URI: http://eprints.mums.ac.ir/id/eprint/7451

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