Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B1

Alizadeh, Ali Mohammad and Mohammadghasemi, Fahimeh and Zendehdel, Kazem and Kamyabi-moghaddam, Zahra and Tavassoli, Abbas and najafi, Fatemeh Amini and Khosravi, Alireza (2015) Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B1. Iranian Journal of Basic Medical Sciences, 18 (1). pp. 8-13.

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Abstract

Objective(s):Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1). Materials and Methods: Twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. The treatment group received FB1 (150 mg/kg diet) for 16 weeks. The gastric atrophy was allocated using grading criteria modeled on the updated Sydney System. Immunohistochemistry studies were performed for evaluation of apoptosis and proliferative activity in gastric mucosa. Results: Mild to moderate gastric atrophy were observed in microscopic findings of the gastric mucosa in treated animals (P<0.05). Number of parietal cells significantly decreased in the treatment group in comparison with the control (P<0.05). Treatment with FB1 for 16 weeks significantly reduced both gastric mucosa height and mitotic index in the gastric glands (P<0.05). TUNEL- and Bax-labeled positive cell numbers significantly increased in the FB1-treated group compared to the control (P<0.05). In addition, proliferative activity of gastric glands in the treated group was significantly lower than the control (P<0.05). Conclusion: Oral administration of FB1 caused atrophy in gastric mucosa both via increasing of apoptosis and suppressing the mitotic activity of these cells.

Item Type: Article
Subjects: QW Microbiology and Immunology
QY Clinical Pathology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 04 Oct 2017 00:12
Last Modified: 04 Oct 2017 00:12
URI: http://eprints.mums.ac.ir/id/eprint/7460

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