Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Yu, Shouli and Shi, Min and Liu, Qinghui and Liu, Changting and Guo, Jun and Yu, Senyang and Jiang, Tingshu (2015) Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats. Iranian Journal of Basic Medical Sciences, 18 (1). pp. 98-103.

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Abstract

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI). Materials and Methods: In this study, we investigated the time course changes of oxidative stress and inflammation in lung tissues of rats exposed to >95 oxygen for 12-60 hr. Results: We found that at 12 hr after hyperoxia challenge, the activities of superoxide dismutase and glutathione peroxidase were significantly reduced with remarkably increased lipid peroxidation. At 12 hr, NF-κB p65 expression was also upregulated, but Iκ-Bα expression showed a remarkable decline. Significant production of inflammatory mediators, e.g, interleukin-1β, occurred 24 hr after hyperoxia exposure. In addition, the expression of intracellular adhesion molecule 1 expression and the activity of myeloperoxidase were significantly increased at 24 hr with a peak at 48 hr. Conclusion: Our data support that hyperoxia-induced oxidative damage and NF-κB pathway activation implicate in the early phase of HALI pathogenesis.

Item Type: Article
Subjects: QW Microbiology and Immunology
QY Clinical Pathology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 04 Oct 2017 00:05
Last Modified: 04 Oct 2017 00:05
URI: http://eprints.mums.ac.ir/id/eprint/7472

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