Three Case of IBD or Exacerbation of IBD after Ovulation Induction

Ganji, Azita and Farhoodi, Mahmoud and Ghaffarzadegan, Kamran and Bikyazdi, Akram (2010) Three Case of IBD or Exacerbation of IBD after Ovulation Induction. medical journal of mashhad university of medical sciences, 53 (3). pp. 189-192.

MJMS_Volume 53_Issue 3_Pages 189-192.pdf

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Introduction Ulcerative colitis (UC) and Crohn�s disease (CD), collectively referred to as inflammatory bowel disease (IBD), present with different histology and cytokine profiles. While the precise mechanisms underlying the development of IBD are not known, sufficient data have been collected to suggest that it results from a complex interplay of genetic , environmental, and immunologic factors. An inappropriate mucosal immune response to normal intestinal constituents is a key feature, leading to an imbalance in local pro- and anti-inflammatory cytokines. Neutrophil and monocyte influx occurs with subsequent secretion of oxygen radicals and enzymes, leading to tissue damage. Case report Here we report three patients with sever symptom of IBD after ovarian stimulation. Conclusion Cytokine profile after ovarian stimulation may contribute to the altered intestinal permeability due to increase in systemic inflammatory cytokines and neutrophil or macrophage activation. In our hypothesis ovulation induction can induce inflammation in intestinal mucosa or exacerbate previous IBD by different cytokines.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 18:09
Last Modified: 03 Oct 2017 18:09

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