Association of HTLV-I with Autoimmune Thyroiditis in Patients withMyelopathy/tropical Spastic Paraparesisand in HTLV-I Carriers

Taghavi, Morteza and Farid Houseni, Reza and Ayatollahi, Hosein (2010) Association of HTLV-I with Autoimmune Thyroiditis in Patients withMyelopathy/tropical Spastic Paraparesisand in HTLV-I Carriers. medical journal of mashhad university of medical sciences, 53 (1). pp. 7-10.

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Abstract

Introduction There are some reports about the association of autoimmune thyroid diseases with human T cell leukemia virus type I (HTLV-I) infection. The objective of this study was to estimate the seroprevalence rates of anti-thyroid antibodies in HTLV-I carriers and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients in Mashhad, north east of Iran, to determine any association between HTLV-I infection and Hashimoto�s thyroiditis (HT). Materials and Methods A total of 46 HTLV-I infected patients (24 patients with HAM/TSP and 22 asymptomatic carriers) and 40 HTLV-I seronegative healthy individuals were screened for the presence of thyroid autoantibodies. The diagnosis of HT was based on the presence of positive thyroid autoantibodies (Anti thyroid peroxidase and/or Anti thyroglobulin) and at least one of two additional criteria (hypothyroidism and/or goiter). Analysis of data was done, using Fisher-Exact test by statistical software SPSS version 13.0. A P value below 0.05 was considered statistically significant. Results Positivity for thyroid autoantibodies was found in 14 (63.6) of 22 asymptomatic carriers, 6 (25) of 24 patients with HAM/TSP and 3 (7.5) of 40 HTLV-I seronegative healthy individuals. HT found in 45.4 of asymptomatic carriers, 25 of HAM/TSP patients and 5 of seronegative healthy individuals. Conclusion This study demonstrates a high prevalence of HT in the HAM/TSP patients and the HTLV-I carriers in Mashhad. Our findings suggest an association between HTLV-I infection and HT in our region.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 18:25
Last Modified: 03 Oct 2017 18:25
URI: http://eprints.mums.ac.ir/id/eprint/7505

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