Evaluation of Subtypes of Peripheral Blood Lymphocytes in Patients with Vitiligo

Tayyebi Meibodi, Naser and Javidi, Zari and Mahmodi, Mahmoud and Maleki, Masoud and Nahidi, Yalda and Afzalaghaei, Monavar and Safaee, Bita and Ebrahimi Rad, Mohammad (2009) Evaluation of Subtypes of Peripheral Blood Lymphocytes in Patients with Vitiligo. medical journal of mashhad university of medical sciences, 52 (4). pp. 198-202.

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Abstract

Introduction Vitiligo is characterized with white patches on the skin and alteration of melanocytes in dermoepidermal junction. Autoimmune mechanisms with an underlying genetic predisposition are the most likely causes of vitiligo. This study was performed to evaluate immune disturbance in vitiligo and clarify its more details. Materials and Methods A total of 29 vitiligo patients and 21 healthy controls were included in this case control study. Complete blood count was measured and peripheral blood samples were evaluated flowcytometrically for surface antigenic markers including CD3, CD4, CD8, CD19, CD16, CD56 and CD25 for determining the percentage and total number of various lymphocyte subgroups. Patients with different clinical subtypes were compared with each other and controls in terms of the flowcytometry results. Obtained information was assessed by SPSS statistical software. Results Total numbers of CD3+, CD8+Â T cells, B cells and CD25+Â cells were significantly increased in generalized type vitiligo patients in comparison with localized type. CD25+Â cells were also increased significantly in generalized and stable types of vitiligo compared with healthy controls and finally the total number of lymphocytes was significantly decreased in localized type vitiligo patients in comparison with healthy controls. Conclusion Our data indicate cellular immune disturbance in vitiligo. Disorders of immune regulatory system may play a major role in this context. Significant CD25+Â or regulatory T cells increment in different clinical subtypes of the disease is in favor of the above hypothesis. Later and larger studies may result in new and effective routs of treatment for vitiligo acting through regulating immune system.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 18:37
Last Modified: 03 Oct 2017 18:37
URI: http://eprints.mums.ac.ir/id/eprint/7514

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