Assessment of the Relation between Hypothyroidism & Serum Level of Ferritin in � Thalassemia Patients

Zndehbad, AzadehSadat and Mirbehbahani, Narghes Beigom (2009) Assessment of the Relation between Hypothyroidism & Serum Level of Ferritin in � Thalassemia Patients. medical journal of mashhad university of medical sciences, 52 (3). pp. 123-128.

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Abstract

Introduction �-thalassemia Major is one of the most common diseases in Iran especially in Golestan province. Blood transfusion has many important complications such as endocrine disorders &amp; Hypothyriodism which can result in disability &amp; untimely mortality. This study was designed to determine the association between Hypothyroidism &amp; serum level of ferritin in these patients. Materials and Methods This study was performed on all patients in thalassemia center of Gorgan (n=185) with age range of 1-37 years. During five years, level of ferritin &amp; T3, T4, TSH were measured every three &amp; 12 months respectively. Data were analyzed using SPSS software. Results Thirty patients had hypothyroidism. Mean age was 17.8 years &amp; male/female ratio was 1. Five patients were under the age of 10. The average level of ferritin at the onset of complication was 2528.400±2157.300 ng/ml. Serum level of ferritin in hypothyroidism, had shown a significant difference in comparison to non-hypothyroid patients (p<0.05). Conclusion This study showed that to prevent hypothyroidism in major thalassemia, we could start clinical &amp; para-clinical studies¸ such as checking serum level of ferritin. Although endocrine abnormalities are usually sought in patients over 10 years of age, we recommend starting the endocrine screening at age 5 since we had 5 patients under the age of ten with these abnormalities.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 18:56
Last Modified: 03 Oct 2017 18:56
URI: http://eprints.mums.ac.ir/id/eprint/7525

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