Comparison of Serum Lead Level in Oral Opium Dependent Men with Healthy Control Group

Salehi, Hosein and Sayadi, Ahmadreza and Zare, Roghiyeh and Soltanpour, Narges and Hoseinpor, Aydin (2009) Comparison of Serum Lead Level in Oral Opium Dependent Men with Healthy Control Group. medical journal of mashhad university of medical sciences, 52 (3). pp. 129-132.

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Introduction  Drug abuse is a major health problem in the Middle East countries such as Iran. Drug dealers may add lead to increase the weight of opium. Several reports have found lead poisoning symptoms in opium dependent patients, which are usually non specific. To the extent of our knowledge, there is no comparative study about blood lead level (BLL) in opium dependent patients with healthy control group. Therefore, the main purpose of this study was comparison of serum lead level in oral opium dependent men with control group.  Materials and Methods  In this study, BLL of forty- four subjects in two patient and control groups was evaluated. The patient group (22 cases) comprised patients who used oral opium. The control group (22 cases) was matched with patient group in age and sex with the mean age of 38.8± 6.7. BLL was assessed immediately, using atomic absorption spectrophotometer.  Results  BLL in the patient group had a range of 7.2 to 69.9 mg/dl (21.9±13.2). In the healthy control group, BLL was between 4.1 and 17.4 mg/dl (8.6±3.5). The mean difference of two groups (t= 4.56) was statistically significant (p<0.0001). In the patient group, BLL had a significant correlation with the amount of opium consumption (r= 0.65, p<0.01). However, there was no such correlation with the length of experience of opium consumption in the patient group.  Conclusion  It would be concluded that the opium dependent patients have elevated BLL compared to the healthy control. Therefore, screening for blood lead concentration is helpful for the opium dependent patients, especially with non-specific symptoms.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 03 Oct 2017 18:57
Last Modified: 03 Oct 2017 18:57

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