Effect of ground black seeds (Nigella sativa L.) on renal tubular cell apoptosis induced by ischemia/reperfusion injury in the rats

Mousavi, Ghafour and Mohajeri, Daryoush (2014) Effect of ground black seeds (Nigella sativa L.) on renal tubular cell apoptosis induced by ischemia/reperfusion injury in the rats. Iranian Journal of Basic Medical Sciences, 17 (12). pp. 1032-1035.

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Abstract

Objective(s): The aim of this study was to evaluate the effects of ground black seeds on renal tubular cell apoptosis following ischemia/reperfusion (I/R) injury in rats. Materials and Methods: Forty male Wistar rats were randomly allocated into 5 equal groups including Sham, I/R model and three I/R+ black seeds (5, 10 and 20)-treated groups. I/R groups’ kidneys were subjected to 60 min of ischemia followed by 24 h of reperfusion. Microscopically, apoptosis of tubular cells was assessed by terminal deoxynucleotidyltransferase-mediated dUTP nick-end labelling (TUNEL) method. Results: The apoptotic cells of renal tubules were increased significantly (P<0.01) in I/R group than those in sham operation group. The TUNEL positive cells in black seeds (10 and 20) treatment groups decreased significantly (P<0.05). Conclusion: Inhibition of apoptosis may be responsible for the protective effects of black seeds in rats with renal I/R injury.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 04 Oct 2017 17:11
Last Modified: 04 Oct 2017 17:11
URI: http://eprints.mums.ac.ir/id/eprint/7545

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