Vitamin D and sepsis

Hariri Ahari, Morteza and Pishbin, Elham (2014) Vitamin D and sepsis. Reviews in Clinical Medicine, 1 (4). pp. 225-228.

RCM_Volume 1_Issue 4_Pages 229-232.pdf

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Vitamin D receptors are located in body tissues and cells. In various physiological processes of the body the primary circulating form of vitamin D, 25-hydroxyvitamin D, will become the active form, 1,25-dihydroxyvitamin D, through many enzymatic. Although different functions of vitamin D has been identified, reducing the possibility of several chronic diseases, including common cancers, autoimmune, infectious, and cardiovascular diseases is proposed as the major role of this component. According to various experimental and clinical studies, vitamin D affects the immune system activity. In this review we study the possible effects of vitamin D on sepsis. The purpose of this review is to evaluate and summarize the role of vitamin D in the immune system, with particular focus on infections and sepsis. We studied different areas related to vitamin D in the literature review including its roles sepsis and infection incidence, as well as seasonal and racial variation in sepsis. Based on evidence, vitamin D positively affects the immune system, so it might act as a therapeutic strategy. Despite several experimental studies which demonstrated the beneficial effects of vitamin D on improved functioning of the immune system, its association with prevention or management of infections and sepsis is not revealed through clinical investigations.

Item Type: Article
Subjects: QU Biochemistry
QW Microbiology and Immunology
Divisions: Journals > Reviews in Clinical Medicine
Depositing User: RCM RCM
Date Deposited: 05 Oct 2017 17:19
Last Modified: 05 Oct 2017 17:19

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