Human activated macrophages and hypoxia: a comprehensive review of the literature

Sotoodehnejadnematalahi, Fattah and Burke, Bernard (2014) Human activated macrophages and hypoxia: a comprehensive review of the literature. Iranian Journal of Basic Medical Sciences, 17 (11). pp. 820-830.

IJBMS_Volume 17_Issue 11_Pages 820-830.pdf

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Macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. Up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro-metastatic genes. On the other hand, macrophages respond to hypoxia by up-regulating several genes which are chief factors in angiogenesis and tumorigenesis. Therefore, in this review article we focus mainly on the role of macrophages during inflammation and discuss their response to hypoxia by regulating a diverse array of transcription factors. We also review the existing literatures on hypoxia and its cellular and molecular mechanism which mediates macrophages activation.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 04 Oct 2017 17:15
Last Modified: 04 Oct 2017 17:15

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