Oxytocin alleviates cisplatin-induced renal damage in rats

Erbas, Oytun and Korkmaz, Huseyin Anil and Oltulu, Fatih and Aktug, Hüseyin and Yavasoglu, Altug and Akman, Levent and Solmaz, Volkan and Taskiran, Dilek (2014) Oxytocin alleviates cisplatin-induced renal damage in rats. Iranian Journal of Basic Medical Sciences, 17 (10). pp. 747-752.

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Abstract

Objective(s):The purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (CP)-induced renal damage in rats. Materials and Methods: Fourteen adult Sprague Dawley rats, weighing 200 to 210, were administered by cisplatin (CP, 2 mg/kg/day) twice a week for five weeks. Then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day) or OT (200 µg/kg/day) for five weeks. Seven rats served as control group. At the end of the treatment period, animals were sacrificed and their kidneys were assessed histologically. In addition, C-reactive protein (CRP), TGF-β and Akt expression were evaluated immunohistochemically. Results:Both tubules and glomeruli were found to be severely damaged with marked medullary tubulo-interstitial inflammation due to chronic cisplatin exposure, particularly in the saline-treated group (Group 1) compared to control group. Oxytocin treatment spared renal tissue significantly by suppressing CRP and TGF-β, and enhancing Akt expression. Conclusion: We conclude that renal damage due to cisplatin toxicity was prevented to a great extent by the anti-inflammatory effect of oxytocin.

Item Type: Article
Subjects: QT physiology
QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 04 Oct 2017 23:56
Last Modified: 04 Oct 2017 23:56
URI: http://eprints.mums.ac.ir/id/eprint/7597

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