Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle

Hu, Liandong and Hu, Qiaofeng and Yang, Jianxue (2014) Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle. Iranian Journal of Basic Medical Sciences, 17 (10). pp. 760-766.

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Objective(s):The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. Materials and Methods: Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins. Results: The optimum formulation F3 consisting of 6 oleic acid, 30 Cremophor RH40/Transcutol P (2:1, w/w) and 59 water phase, showed a high permeation rate of 42.98 μg/cm2/hr. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits. Conclusion: These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 05 Oct 2017 00:00
Last Modified: 05 Oct 2017 00:00
URI: http://eprints.mums.ac.ir/id/eprint/7599

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