Comparison between efficacy of Tamsulosin and Terazosinin alpha-adrenergic blockers in spontaneous passage of ureter stones after ESWL (A double blind clinical trial)

Pedram, Pardis and Tajari, Hamid Reza and Keshtkar, Abbas Ali and Ghazi Moghadam, Behroz and Amidi, Aref (2009) Comparison between efficacy of Tamsulosin and Terazosinin alpha-adrenergic blockers in spontaneous passage of ureter stones after ESWL (A double blind clinical trial). medical journal of mashhad university of medical sciences, 52 (2). pp. 87-94.

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Abstract

Introduction Nephrolithiasis has a high prevalence in population. Our objective was to compare time of stone passage, severity of pain, frequency of the use of analgesics and the course of disability between groups A, B and C. Materials and Methods In this randomized controlled trial study, 240 patients were selected .inclusion criteria was all patient with 5-9mm stone diameter, and exclusion criteria was opium addiction. All of patients were categorized in 3 groups with Block Balance Randomize and double blind method. Each group consisted of 80 persons. In group A (i.e. control group) patients were given daily Diclofenac suppositories of 100mg and Diclofenac tablets of 25mg.In group B patients were given Tamsulosin tablets of 0.4 mg in addition to routine treatment and in group C patients were given Terazosin tablets of 2 mg in addition to routine treatment. Patients were visited three months after lithotripsy. Results The rate of ureteral stone passage in group B (85.5)was more than group A (80) and group C (83.3), the mean expulsion time group A with 14.9 days was more than group B (12.1 days) and group C (12.2 days),also severity of pain on the basis of VAS chart in group B (4.7) less than group A (5.5) and C (5.2), extra analgesic requirement in α blockers group (B:4 patients and C:2 patients) less than control group (8 patients), and all of these were non significantly different Conclusion α blockers are decrease symptoms of pain and no effective response on expulsion of stones.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 05 Oct 2017 14:22
Last Modified: 05 Oct 2017 14:22
URI: http://eprints.mums.ac.ir/id/eprint/7664

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