The Pre-emptive Analgesic Effect of Peritonsillar Infiltration of Ketamine for Postoperative Pain Relief in Children Following Tonsillectomy

Safavi, Mohammadreza and Honarmand, Azim and Barati, Behroz and Mahjobipor, Hossein (2009) The Pre-emptive Analgesic Effect of Peritonsillar Infiltration of Ketamine for Postoperative Pain Relief in Children Following Tonsillectomy. medical journal of mashhad university of medical sciences, 52 (1). pp. 37-42.

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Abstract

Introduction  In several studies, theuse of ketamine for the preemptive analgesiain the management of postoperative pain is controversial. The purpose of our study was the clinical assessment of the efficacy of preincisional peritonsillar infiltration of two doses of ketamineon postoperative pain relief compared with preincisional peritonsillar infiltration of saline in children undergoing tonsillectomy.  Materials and Methods  A total of Seventy-five ASA (American Society Anesthesia) physical status I and II patients, aged 3 to 12 years, scheduled for tonsillectomy were enrolled in this randomized, double-blinded, placebo-controlled study.Patients were divided into three groups of 25 each and received a local peritonsillarinfiltration of 0.9 saline (Group A), ketamine 0.5 mg/kg (Group B), or ketamine 1 mg/kg (Group C). All medications were 2 ml in volume which applied 1 ml per tonsil 3 min prior to tonsillectomy. The Children's Hospital Eastern Ontario Pain Scale (CHEOPS)and Wilson sedation scale were used to evaluate pain levels and sedative condition,respectively.  Results  Group A had significantly higher CHEOPS scores than group B and group C. Group B and group C had comparable scores, which were not statistically significant (p> 0.05). During 24 hours after surgery, sixteen patients in group A and no patients in groups B or C needed analgesics (p< 0.001).  Conclusion  0.5 or 1 mg/kg dose of ketamine, given at approximately 3 min before surgery by peritonsillar infiltration, provides efficient pain relief without side-effects in children undergoing tonsillectomy.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 05 Oct 2017 14:34
Last Modified: 05 Oct 2017 14:34
URI: http://eprints.mums.ac.ir/id/eprint/7688

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