Leukocyte Adhesion Deficiency

Behmanesh, Fatemeh and Banihashem, Abdollah (2008) Leukocyte Adhesion Deficiency. medical journal of mashhad university of medical sciences, 51 (4). pp. 243-246.

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Introduction Leukocyte adhesion deficiency (LAD) is a rare functional leukocyte disorder, which is divided into two separate types: LAD-1 and LAD-2. LAD-1 results from lack of b2Â integrin molecules (CD11 & CD18) on the leukocyte cell surface. These molecules are essential for leukocyte adhesion to endothelial cells and chemotaxis. The present case report is about a 42-month-old girl with recurrent otitis, pneumonia and gingivitis. On physical examination, patient was pale and malnourished. Multiple desquamated erythematous plagues were found on her body and extremities. Blood investigations revealed persistent leukocytosis with normal serum Immunoglobulin profile and complement. The diagnosis of LAD1 was made based on Flow cytometry finding; showing decreased in CD11 and CD18 markers of PMN a. Conclusion When a patient has persistent leukocytosis and recurrent infections, investigation for the primary immune deficiency, specially leukocyte adhesion deficiency must be considered.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 05 Oct 2017 15:41
Last Modified: 05 Oct 2017 15:41
URI: http://eprints.mums.ac.ir/id/eprint/7707

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