Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method

Akhgari, Abbas and Sadeghi, Hasti and Dabbagh, Mohammad Ali (2014) Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method. Iranian Journal of Basic Medical Sciences, 17 (8). pp. 553-559.

[img]
Preview
Text
IJBMS_Volume 17_Issue 8_Pages 553-559.pdf

Download (1MB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_3185.html

Abstract

Objective(s):The aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. Quasi-emulsion solvent diffusion was used as a crystal modification method. Materials and Methods: Corn starch was dissolved in hydrochloric acid at 80˚C and then ethanol as a non-solvent was added with lowering temperature until the formation of a precipitate of modified starch. Flow parameters, particle size and thermal behavior of the treated powders were compared with the native starch. Finally, the 1:1 mixture of naproxen and each excipient was tabletted, and hardness and friability of different tablets were evaluated. Results: Larger and well shaped agglomerates were formed which showed different thermal behavior. Treated starch exhibited suitable flow properties and tablets made by the treated powder had relatively high hardness. Conclusion: It was found that recrystallization of corn starch by quasi emulsion solvent diffusion method could improve its flowability and compressibility characteristics.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 07 Oct 2017 16:02
Last Modified: 07 Oct 2017 16:02
URI: http://eprints.mums.ac.ir/id/eprint/7790

Actions (login required)

View Item View Item