The association between inflammatory markers and obesity-related factors in Tehranian adults: Tehran lipid and glucose study

Faam, Bita and Zarkesh, Maryam and Daneshpour, Maryam Sadat and Azizi, Fereidoun and Hedayati, Mehdi (2014) The association between inflammatory markers and obesity-related factors in Tehranian adults: Tehran lipid and glucose study. Iranian Journal of Basic Medical Sciences, 17 (8). pp. 577-582.

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Abstract

Objective(s):Obesity considered being a low-grade inflammatory disease. The objective of this study was to examine the association between inflammatory markers (IM) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and homocystein (Hcy) and obesityF1 -related factors (e.g. BMI, waist, hip) in adult participants of Tehran lipid and glucose study (TLGS). Materials and Methods: In this cross-sectional study, 352 individuals (132 men and 220 women), age ≥19 years, were randomly recruited from participants of TLGS populationF2 . The serum levels of hs-CRP, IL-6, Hcy were determined using the enzyme linked immunosorbent assay (ELISA) methodF3 . Variables were compared by sample t-test. Bivariate linear correlation was estimated using Pearson’s correlation coefficient. Linear regression analysis was applied to investigate the association between IMs and anthropometric and biochemical variables. Results: The mean age of participants was 46.1±16.1 years. abdominal obesity was present in 199(56.5%) individuals. levels of hs-CRP and IL-6 increased in the abdominally obese group (1507±3.3 vs. 577.8±4.3 ng/ml P<0.001) (3.6±3.3 vs. 1.9±3.8 pg/ml P< 0.001), and in the same group, the best predictors for hs-CRP, IL-6 and Hcy were waist (WC), waist to height ratio (WHtR) and wrist respectively; hip and WHtR were the best predictors for Hcy and hs-CRP in the normal group. A linear augmentation in hs-CRP and IL-6 levels was observed in association with obesity categorizes. Conclusion: This study provides evidence that abdominally obese individuals had higher levels of IMs. Wrist, waist and WHtR were the best predictors for Hcy, hs-CRP and IL-6 respectively in this group.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 07 Oct 2017 15:43
Last Modified: 07 Oct 2017 15:43
URI: http://eprints.mums.ac.ir/id/eprint/7793

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