Effect of leptin receptor Q223R polymorphism on breast cancer risk

Mohammadzadeh, Ghorban and Ghaffari, Mohammad-Ali and Bafandeh, Ahmmad and Hosseini, Sayed-Mohammad (2014) Effect of leptin receptor Q223R polymorphism on breast cancer risk. Iranian Journal of Basic Medical Sciences, 17 (8). pp. 588-594.

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Abstract

Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method to investigate the association ofLEPRQ223R polymorphism with breast cancer risk in a case control study consisting of 100 breast cancer cases and 100 controls without breast cancer. Serum levels of leptin and soluble leptin receptor (sOB-R) were measured by ELISA method. Results:The genotype (QQ, QR, and RR) distributions were 25, 56, and 19 in breast cancer cases and 54, 40, and 6 in controls, respectively. The frequency of 223 RR genotype was significantly elevated in breast cancer cases as compared to controls (χ2= 20.072, P<0.001). Similar significance differences were also found in allele frequencies for Q and R between two groups (χ2= 19.027, P< 0.001). Additionally, there weresignificant association between Q223R genotypes and breast cancer risk; homozygotes for RR genotype (OR= 6.840; 95 confidence interval CI = 2.434-19.218), heterozygotes for QR (OR=3.024; 95% CI = 1.620-5.644, P = 0.001), and QR+RR genotype (OR= 3.522; 95% CI = 1.934-6.414, P < 0.001), respectively. Conclusion:Our results showed thattheLEPRQ223R polymorphism is associated with increased breast cancer risk as well as tumor grade in a sample of Iranian subjects.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 07 Oct 2017 15:48
Last Modified: 07 Oct 2017 15:48
URI: http://eprints.mums.ac.ir/id/eprint/7796

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