Oxidative stress in COPD, pathogenesis and therapeutic views

Rezaeetalab, Fariba and Hamidi alamdari, Daryush and Dalili, Asghar (2014) Oxidative stress in COPD, pathogenesis and therapeutic views. Reviews in Clinical Medicine, 1 (3). pp. 115-124.

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Abstract

Chronic obstructive pulmonary disease (COPD), characterised by partially reversible contracture of small respiratory airways seems to be among leading causes of death in the world. COPD is characterized by inflammation, protease/antiprotease imbalance, genetic variability and oxidative stress. The latter refers to a condition in which oxidative agents overcome against antioxidants. In this review literature, the consequences of oxidative stress in COPD, such as systemic and pulmonary neutrophil influx, hypersecretion, dual and reciprocal effects with inflammatory contributors and systemic manifestations are discussed. In addition, a review of oxidative stress biomarkers as well as therapeutic strategies based on recent researches for antioxidant supplementation therapy is provided.

Item Type: Article
Subjects: WF Respiratory System
QU Biochemistry
Divisions: Journals > Reviews in Clinical Medicine
Depositing User: RCM RCM
Date Deposited: 05 Oct 2017 18:13
Last Modified: 05 Oct 2017 18:13
URI: http://eprints.mums.ac.ir/id/eprint/7811

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